Preparation and identification of new ligands derived from 5-aminoindole and their complexes with some metal ions, and evaluated their effectiveness as antioxidants and breast cancer fighters; A doctoral thesis.


The doctoral thesis was discussed in the Chemistry Department at the College of Education at Al-Qadisiyah University. It was presented by researcher Sarab Rahman Salman Al-Qaseer, under the supervision of Professor Dr. Haider Obaid Jamel and Assistant Professor Dr. Ghusoon Faydi Hamid.

The thesis aimed to prepare three new heterocyclic Schiff base ligands derived from 5-aminoindole by reacting them with a number of metal ion salts, namely: nickel(II), copper(II), palladium(II), platinum(IV), gold(III), and nitrates. Silver(I)

Key Conclusions: The preparation results showed that nickel(II), copper(II), and platinum(IV) complexes formed in a molar ratio [M:L] = [1:2] with all three ligands, while the silver(I), palladium(II), and gold(III) complexes showed a molar ratio of [1:1], indicating that the coordination pattern between these complexes varies depending on the metal type.

Key Recommendations: In light of the results that demonstrated the effectiveness of some Schiff base ligands (L1H, L2H), (HL3) and their metal complexes against cancer cells, it is recommended to conduct extensive biological studies to test their potential use as therapeutic compounds, whether as antitumor agents or as inhibitors of some chronic diseases, with the possibility of later developing them as an effective pharmaceutical agents.

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